Concepedia

9-Aminoacridine-based anticancer drugs target the PI3K/AKT/mTOR, NF-κB and p53 pathways

Chuanbin Guo, A. V. Gasparian, Zhengping Zhuang, Dmitriy A. Bosykh, Anton A. Komar, Andrei V. Gudkov, Katerina V. Gurova

Oncogene · 2009 · 116 citations · 19 references

DOI

Concepts

References

19

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

Dos D. Sarbassov, David A. Guertin, Siraj M. Ali et al. · Science · 2005 · 6.2K citations

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NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

Osman Nidai Özeş, Lindsey D. Mayo, Jason A. Gustin et al. · Nature · 1999 · 2.2K citations

, , +16

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

Andrei V. Budanov, Michael Karin · Cell · 2008 · 1.3K citations · Full text

, , +14

The coordinate regulation of the p53 and mTOR pathways in cells

Zhaohui Feng, Haiyan Zhang, Arnold J. Levine · Proceedings of the National Academy of Sciences · 2005 · 1.2K citations

, , +17

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

Lindsey D. Mayo, David B. Donner · Proceedings of the National Academy of Sciences · 2001 · 1.2K citations · Full text

, , +16