Concepedia

A QSAR study comparing the cytotoxicity and DNA topoisomerase II inhibitory effects of bisdioxopiperazine analogs of ICRF-187 (dexrazoxane)

Brian B. Hasinoff, Theodore I. Kuschak, Jack C. Yalowich, Andrew M. Creighton

Biochemical Pharmacology · 1995 · 108 citations · 29 references

DOI

Concepts

References

29

Adriamycin-Induced DNA Damage Mediated by Mammalian DNA Topoisomerase II

K M Tewey, Thomas C. Rowe, Liu Yang et al. · Science · 1984 · 1.5K citations

, , +17

Antitumor bisdioxopiperazines inhibit yeast DNAtopoisomerase II by trapping the enzyme in the form of a closed proteinclamp.

Joaquím Roca, Ryoji Ishida, James M. Berger et al. · Proceedings of the National Academy of Sciences · 1994 · 354 citations · Full text

, , +12

ICRF-187 permits longer treatment with doxorubicin in women with breast cancer.

James L. Speyer, M D Green, Anne Zeleniuch‐Jacquotte et al. · Journal of Clinical Oncology · 1992 · 323 citations

, , +17

The capture of a DNA double helix by an ATP-dependent protein clamp: A key step in DNA transport by type II DNA topoisomerases

Joaquím Roca, James C. Wang · Cell · 1992 · 312 citations

, , +7

Inhibition of topoisomerase II by antitumor agents bis(2,6-dioxopiperazine) derivatives.

K Tanabe, Yoji Ikegami, Ryoji Ishida et al. · PubMed · 1991 · 297 citations

, , +10