Highly Enantioselective Catalytic Conjugate Additions to Cyclohexadienones

Abstract

Enantioselective copper phosphoramidite-catalyzed conjugate addition of dialkylzinc reagents (R2Zn) to several 4,4-disubstituted cyctohexadienones was achieved with dr's up to 99/1 and ee's up to 99%.