Highly Enantioselective Catalytic Conjugate Addition and Tandem Conjugate Addition–Aldol Reactions of Organozinc Reagents

Abstract

Complete stereocontrol with the added advantage of functional-group tolerance in copper-catalyzed 1,4-additions of organozinc reagents to enones has been achieved for the first time with the chiral phosphoramidite L* as ligand in the copper complex [Eq. (a), Tf = trifluoromethanesulfonate]. The zinc enolate intermediate of the reaction can be trapped with aldehydes.