Antiangiogenic effects of anti–tumor necrosis factor α therapy with infliximab in psoriatic arthritis

Abstract

These results show consistent changes in several factors involved in angiogenesis regulation, in parallel with the clinical response to infliximab in patients with PsA. The pattern of reduced VEGF with increased Ang-2 suggests vascular regression as a potential mechanism underlying the antiangiogenic effect of infliximab.