Visualized absorption of anti‐atherosclerotic dipeptide, Trp‐His, in Sprague–Dawley rats by LC‐MS and MALDI‐MS imaging analyses

Abstract

To the best of our knowledge, this is the first study demonstrating that the vasoactive Trp-His is preferably transported across the rat intestinal membrane by PepT1 and is absorbed intact into the circulation. However, no absorption of His-Trp, a reverse sequence of absorbable Trp-His, is observed owing to hydrolysis by intestinal proteases. This suggests that the bioavailability of peptides may be determined in part by their protease resistance in the intestinal membrane.