Controlling programmed cell death with a cyclophilincyclosporin-based chemical inducer of dimerization

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

Jun S. Liu, Jesse D. Farmer, Willam S. Lane et al. · Cell · 1991 · 4.1K citations

Protein Function, Signal Transduction, Biochemistry +9

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

Marta Muzio, Arul M. Chinnaiyan, Frank Kischkel et al. · Cell · 1996 · 3K citations · Full text

Death-inducing Signaling Complex, Signal Transduction, Signaling Pathway +11

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

Naoto Itoh, Shin Yonehara, Ai Ishii et al. · Cell · 1991 · 2.8K citations

Molecular Immunology, Apoptosis, Immunology +9

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

Arul M. Chinnaiyan, Karen O’Rourke, Muneesh Tewari et al. · Cell · 1995 · 2.4K citations · Full text

Mitophagy, Protein Function, Signal Transduction +11

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

Mark Boldin, Tanya Goncharov, Yury V Goltseve et al. · Cell · 1996 · 2.3K citations · Full text

Inflammation, Novel Mort1/fadd-interacting Protease, Protein Function +10