Concepedia

Loss-of-Function Mutation in Tryptophan Hydroxylase-2 Identified in Unipolar Major Depression

Xiao-Dong Zhang, Raul R. Gainetdinov, Jean‐Martin Beaulieu, Tatyana D. Sotnikova, Lauranell H. Burch, Redford B. Williams, David A. Schwartz, K. Ranga Krishnan, Marc G. Caron

Neuron · 2005 · 465 citations · 24 references

Open access

Concepts

Life SciencesGeneticsPsychiatryMolecular NeuroscienceNeurogeneticsPsychopharmacologyDepressionDepressive DisordersEnzyme DeficienciesGenetic DisordersPsychiatric GeneticsPsychiatric PharmacogenomicsDepression GeneticsDepression PathophysiologyLoss-of-function VariantsMajor DepressionMajor Depressive Disorder GeneticsTryptophan HydroxylationTryptophan Metabolism

References

24

<tt>BLAT</tt>—The <tt>BLAST</tt>-Like Alignment Tool

W. James Kent · Genome Research · 2002 · 8.4K citations · Full text

Life Sciences, Bioinformatics, Molecular Biology +16

Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene

Avshalom Caspi, Karen Sugden, Terrie E. Moffitt et al. · Science · 2003 · 8.1K citations

Life Sciences, Genetics, Molecular Genetics +17

Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region

Klaus‐Peter Lesch, Dietmar Bengel, Armin Heils et al. · Science · 1996 · 5.2K citations

Life Sciences, Genetics, Molecular Genetics +17

Fluoxetine, Cognitive-Behavioral Therapy, and Their Combination for Adolescents With Depression

John S. March, Susan G. Silva, Stephen Petrycki et al. · JAMA · 2004 · 1.7K citations · Full text

Pharmacy, Pharmacotherapy, Psychiatry +17

Synthesis of Serotonin by a Second Tryptophan Hydroxylase Isoform

Diego J. Walther, Jens‐Uwe Peter, Saleh Bashammakh et al. · Science · 2003 · 1.6K citations

Medicine, Neuroscience, Pharmacology +15