FEBS Letters · 1989 · 166 citations · 18 references
Life SciencesBiochemistryMolecular BiologyEnzymologyMolecular VirologyVirologyEnzyme InhibitionEnzyme KineticsAntiviral Mechanisms Of ActionAspartic ProteasesBlockingIonic StrengthIonic Strength DependenceIonic Strength EffectsViral Protease InhibitionViral Replication Inhibitors
Inhibitory constants (Ki) between 5 and 35 nM were derived (under different conditions of pH and ionic strength) for the interaction of HIV-1 proteinase with acetyl-pepstatin and H-261, two characteristic inhibitors of aspartic proteinases. Thus this enzyme, essential for replication of the AIDS virus, may be classified unequivocally as belonging to this proteinase family.
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A structural model for the retroviral proteases
Laurence H. Pearl, William R. Taylor · Nature · 1987 · 599 citations
Crystal structure of a retroviral protease proves relationship to aspartic protease family
Maria Miller, Mariusz Jaskólski, Jayasimha Rao et al. · Nature · 1989 · 344 citations