Laurence H. Pearl

Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone

Chrisostomos Prodromou, S. Mark Roe, Ronan O’Brien et al. · Cell · 1997 · 1.3K citations · Full text

Atp/adp-binding Site, Structural Characterization, Protein Function +11

Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin

S. Mark Roe, Chrisostomos Prodromou, Ronan O’Brien et al. · Journal of Medicinal Chemistry · 1999 · 991 citations · Full text

Protein Assembly, Molecular Biology, Antimicrobial Chemotherapy +20

Crystal structure of an Hsp90–nucleotide–p23/Sba1 closed chaperone complex

Maruf M. U. Ali, S. Mark Roe, Cara K. Vaughan et al. · Nature · 2006 · 959 citations · Full text

Crystal Structure, Biochemistry, Protein Folding +7

GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins

Laurent Meijer, Alexios-Leandros Skaltsounis, Prokopios Magiatis et al. · Chemistry & Biology · 2003 · 807 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Gsk-3-selective Inhibitors +6

Crystal Structure of Glycogen Synthase Kinase 3β

Rana Dajani, Elizabeth Fraser, S. Mark Roe et al. · Cell · 2001 · 657 citations · Full text

Crystal Structure, Protein X-ray Crystallography, Molecular Biology +2