?-endorphin-sensitive opioid receptors in the rat tail artery

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Endogenous opioid peptides: multiple agonists and receptors

John A.H. Lord, Angela A. Waterfield, John Hughes et al. · Nature · 1977 · 2.5K citations

Medicine, Pharmacology, Neuroendocrinology +9

β-Endorphin and Adrenocorticotropin Are Selected Concomitantly by the Pituitary Gland

Roger Guillemin, Therese Vargo, Jean Rossier et al. · Science · 1977 · 1.4K citations

Life Sciences, Endocrinology, Neurobiology +15

Dynorphin Is a Specific Endogenous Ligand of the κ Opioid Receptor

Charles Chavkin, Iain F. James, Avram Goldstein · Science · 1982 · 1.2K citations

Medicine, Medicinal Chemistry, Pharmacology +17

Distribution of peptide- and catecholamine-containing neurons in the gastro-intestinal tract of rat and guinea-pig: Immunohistochemical studies with antisera to substance P, vasoactive intestinal polypeptide, enkephalins, somatostatin, gastrin/cholecystokinin, neurotensin and dopamine β-hydroxylase

Marianne Schultzberg, T. Hökfelt, Göran Nilsson et al. · Neuroscience · 1980 · 889 citations

Life Sciences, Neurobiology, Neuroscience +15