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Synthesis and biological activity of 5-aryl-4-(4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl)pyrimidine analogs as potent, highly selective, and orally bioavailable NHE-1 inhibitors

Biological ActivityBioavailable Nhe-1 InhibitorsMedicinal ChemistryPyrimidine AnalogsBiochemistryNatural SciencesMedicinePharmacological AgentPharmacotherapyDrug DevelopmentChemical BiologyPharmacologyPharmaceutical ChemistryDrug Discovery