Design and Synthesis of <i>N</i>-[(4-Methoxyphenoxy)carbonyl]-<i>N</i>-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a Novel Peroxisome Proliferator-Activated Receptor α/γ Dual Agonist with Efficacious Glucose and Lipid-Lowering Activities

Pratik Devasthale, Sean Chen, Yoon Jeon, +28

Journal of Medicinal Chemistry

The Novel Neuropeptide Y Y5 Receptor Antagonist Lu AA33810 [N-[[trans-4-[(4,5-Dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] Exerts Anxiolytic- and Antidepressant-Like Effects in Rat Models of Stress Sensitivity

Mary W. Walker, Toni D. Wolinsky, Vrej Jubian, +11

Journal of Pharmacology and Experimental Therapeutics

Expression of sucrase-isomaltase mRNA along the villus-crypt axis in the rat small intestine.

Gamini Chandrasena, Iruvanti Sunitha, Lau C, +2

PubMed

GastroenterologyPathologyRat Small IntestineCell DifferentiationDigestive Tract +18

3-Arylimino-2-indolones Are Potent and Selective Galanin GAL₃ Receptor Antagonists

Michael J. Konkel, Bharat Lagu, Lakmal W. Boteju, +13

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryBiochemistryMedicineNatural Sciences +12

Functional expression of human intestinal Na+-dependent and Na+-independent nucleoside transporters in Xenopus laevis oocytes

Gamini Chandrasena, Richard Giltay, Shivakumar D. Paul, +2

Biochemical Pharmacology

Molecular PhysiologySignal TransductionNa+-independent Nucleoside TransportersXenopus Laevis OocytesCell Signaling +10

Synthesis and biological activity of 5-aryl-4-(4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl)pyrimidine analogs as potent, highly selective, and orally bioavailable NHE-1 inhibitors

Karnail S. Atwal, Steven V. O’Neil, Saleem Ahmad, +6

Bioorganic & Medicinal Chemistry Letters

Biological ActivityBioavailable Nhe-1 InhibitorsMedicinal ChemistryPyrimidine AnalogsBiochemistry +9

Lack of Exposure in a First-in-Man Study Due to Aldehyde Oxidase Metabolism: Investigated by Use of 14C-microdose, Humanized Mice, Monkey Pharmacokinetics, and In Vitro Methods

Klaus Gjervig Jensen, Anne‐Marie Jacobsen, Christoffer Bundgaard, +4

Drug Metabolism and Disposition

Quantitative Analysis of Lipids: A Higher-Throughput LC–MS/MS-Based Method and its Comparison to ELISA

Adarsh Gandhi, David Budac, Tanzilya Khayrullina, +2

Future Science OA

Identification and optimization of a novel series of [2.2.1]-oxabicyclo imide-based androgen receptor antagonists

Mark Salvati, Aaron Balog, Weifang Shan, +16

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryNovel SeriesBiochemistryMedicineNatural Sciences +8

Inhibition of the potassium channel K Ca 3.1 by senicapoc reverses tactile allodynia in rats with peripheral nerve injury

Roland G. W. Staal, Tanzilya Khayrullina, Hong Zhang, +14

European Journal of Pharmacology

Hyperpolarization (Biology)NeurophysiologyNeuroanatomyMedicinePhysiology +12