STAT3 silencing enhances the efficacy of the HSV.tk suicide gene in gastrointestinal cancer therapy

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

Guilian Niu, Kenneth L. Wright, Mei Huang et al. · Oncogene · 2002 · 1.2K citations

Medicine, Cancer Biology, Pathobiology +12

Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome

Yoshiyuki Minegishi, Masako Saitō, Shigeru Tsuchiya et al. · Nature · 2007 · 1K citations

Life Sciences, Genetics, Immunology +13

Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

Marcin Kortylewski, Maciej Kujawski, Tianhong Wang et al. · Nature Medicine · 2005 · 1K citations

Medicine, Hematology, Immunology +14

Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo.

Gang Niu, Richard Heller, Robyn Catlett-Falcone et al. · PubMed · 1999 · 315 citations

Medicine, Molecular Biology, Oncology +15

Activation of STAT3 is a marker of poor prognosis in human colorectal cancer

Takafumi Kusaba, Toshiyuki Nakayama, Kazuyuki Yamazumi et al. · Oncology Reports · 2006 · 243 citations · Full text

Medicine, Molecular Biology, Oncology +12