Cell Biochemistry and Function · 2011 · 111 citations · 37 references
MedicineOncologyPharmacologyCell SignalingSignal TransductionTumor ProgressionCancer Cell SignalingCancer ProgressionMetastatic Signaling PathwaysOncogenic Signaling PathwaysProstate CancerSignal Transduction In CancerCancer Cell Proliferation InhibitionCancer Cell Survival SignalingEpidermal Growth Factor Receptor InhibitionEpidermal Growth Factor Receptor SignalingMetastasis SuppressionProtein Kinase C SignalingSerine Protease Mechanism
Urokinase-type plasminogen activator (uPA) is a serine protease that is involved in cancer progression, especially invasion and metastasis including prostate cancer. uPA activation is mediated by transactivation of uPAR and epidermal growth factor receptor (EGF-R) in prostate cancer progression. Prostate cancer (PC-3) cells have highly invasive capacity and they express uPA and uPAR gene. PC-3 cells are treated with quercetin, which inhibits invasion and migration of PC-3 cells. Quercetin downregulates uPA, uPAR and EGF, EGF-R mRNA expressions. Quercetin inhibits cell survival factor β-catenin, NF-κB and also proliferative signalling molecules such as p-EGF-R, N-Ras, Raf-1, c.Fos c.Jun and p-c.Jun protein expressions. But quercetin increased p38 mitogen-activated protein kinase protein expression. Our results suggest that quercetin inhibit migration and invasion of prostate cancer cells. It shows the value for treatment of invasive and metastasis type of prostate cancer.
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