Antimicrobial Agents and Chemotherapy · 2001 · 39 citations · 28 references
Life SciencesInfectious DiseasesMicrobiologyAntimicrobial ResistanceMedical MicrobiologyMicrobial PathogenesisAcquired ResistanceAntibacterial ResistanceAntibiotic ResistanceAntibiotic Resistance MechanismsBacterial InfectionsMechanisms Of Antimicrobial ResistanceEscherichia ColiFluoroquinolone Resistance MechanismsLincosamide ResistanceMacrolide AntibioticsMutation-driven ResistanceMutational Pathways Of ResistancePoint MutationsResistance-suppressing Mutations
We describe two mutants of Mycoplasma hominis PG-21 which show resistance to 16-membered macrolides but susceptibility to lincosamides, obtained by in vitro exposure to increasing doses of josamycin. The 23S rRNA gene showed that each had a mutation (A2062G and A2062T) corresponding to nucleotide 2062 in Escherichia coli, which was associated with the acquired phenotype.
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