Depleting MEKK1 expression inhibits the ability of invasion and migration of human pancreatic cancer cells

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

Concepción Almoguera, Darryl Shibata, Kathleen Forrester et al. · Cell · 1988 · 2.1K citations

Medicine, Molecular Genetics, Oncology +10

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

Sarah P. Thayer, Marina Pasca di Magliano, Patrick W. Heiser et al. · Nature · 2003 · 1.5K citations · Full text

Medicine, Cancer Biology, Oncology +12

K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization.

Ralph H. Hruban, A D van Mansfeld, G.J.A. Offerhaus et al. · PubMed · 1993 · 653 citations

Medicine, Molecular Genetics, Oncology +15

High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma

Yousuke Seo, Hideo Baba, Toshiro Fukuda et al. · Cancer · 2000 · 402 citations

Medicine, Oncology, Pathology +15

The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-κB and c-Myc in pancreatic cancer cells

Takayuki Asano, Yixin Yao, Jijiang Zhu et al. · Oncogene · 2004 · 298 citations

Medicine, Molecular Biology, Oncology +16