Genetic Variation in the G-50T Polymorphism of the Cytochrome P450 Epoxygenase <i>CYP2J2</i> Gene and the Risk of Younger Onset Type 2 Diabetes among Chinese Population: Potential Interaction with Body Mass Index and Family History - Concepedia

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Genetic Variation in the G-50T Polymorphism of the Cytochrome P450 Epoxygenase <i>CYP2J2</i> Gene and the Risk of Younger Onset Type 2 Diabetes among Chinese Population: Potential Interaction with Body Mass Index and Family History

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2010

Year

C.-P. Wang, Wei‐Chieh Hung, Tung‐Min Yu, C. Chiu, Lingyi Lu, Fu‐Mei Chung, Chun Ho Hung, SG Shin, H.-J. Chen, Y.-J. Lee

Experimental and Clinical Endocrinology & Diabetes

Abstract

These data suggest that age of onset, family history, and obesity may modify the association between the CYP2J2 G-50T polymorphism and T2DM risk. CYP2J2 G-50T polymorphism may contribute to the pathogenesis of T2DM, partially by effects on insulin resistance, in patients with younger onset T2DM.