Contribution of bioinformatics predictions and functional splicing assays to the interpretation of unclassified variants of the BRCA genes

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

M. William Audeh, James Carmichael, Richard T. Penson et al. · The Lancet · 2010 · 2.3K citations

Medicine, Gynecology, Oncology +16

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

Andrew Tutt, Mark E. Robson, Judy E. Garber et al. · The Lancet · 2010 · 1.6K citations

Medicine, Oncology, Pharmacotherapy +13

Comprehensive statistical study of 452 BRCA1 missense substitutions with classification of eight recurrent substitutions as neutral

Sean V. Tavtigian · Journal of Medical Genetics · 2005 · 665 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Detection of inherited mutations for breast and ovarian cancer using genomic capture and massively parallel sequencing

Tom Walsh, Ming K. Lee, Silvia Casadei et al. · Proceedings of the National Academy of Sciences · 2010 · 491 citations

Life Sciences, Genetics, Oncology +17

A Systematic Genetic Assessment of 1,433 Sequence Variants of Unknown Clinical Significance in the BRCA1 and BRCA2 Breast Cancer–Predisposition Genes

Douglas F. Easton, Amie M. Deffenbaugh, Dmitry Pruss et al. · The American Journal of Human Genetics · 2007 · 451 citations · Full text

Life Sciences, Genetics, Molecular Genetics +16