Studies on the fate of isotopically labeled metabolites in the oxidative metabolism of tumors.

Abstract

This phenomenon is known as the Pasteur Effect, being similar to the inhibition of fermentation by oxygen, observed many years ago by Pasteur in various microorganisms. Warburg (13) found that tumor tissues also displayed this Pasteur Effect and to about the same extent, quantitatively, as normal tissues. He also found that the rates of oxy gen consumption, though on the low side, were within the range of those of normal tissues. In con trast to normal tissues, however, the level of lactic acid production was extremely high in tumors, so that even with a “normal― Pasteur Effect lactic