Publication | Closed Access
An Enzymatic Route to Florfenicol
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1991
Year
Bioorganic ChemistryEngineeringStreptomyces GriseusOrganic ChemistryEnzymatic ModificationBiosynthesisRacemic Ethyl Threo-3-Metabolic EngineeringNatural Product BiosynthesisStereoselective SynthesisEnzymatic HydrolysisBiotransformationBiochemistryBiocatalysisNatural Product SynthesisEnzymatic RouteBiomolecular EngineeringAlkene MetathesisNatural SciencesBiotechnology
Racemic ethyl threo-3-(4-methylthiophenyl)serinate is resolved by enzymatic hydrolysis using protease from Streptomyces griseus and both stereoisomers are converted to D-threo-4, 5-dihydro-5-(4-methylsulfonylphenyl)-2-phenyl-4-oxazolemethanol, thereby giving a formal synthesis of florfenicol.