<i>E</i>/<i>Z</i>-Rubrolide O, an Anti-inflammatory Halogenated Furanone from the New Zealand Ascidian <i>Synoicum</i> n. sp.

Abstract

Bioassay-directed fractionation of extracts of a Synoicum n. sp. ascidian from New Zealand led to the isolation of the principal anti-inflammatory component, which was identified by spectroscopic methods as a new member of the rubrolide family, rubrolide O (1), existing as a mixture of E/Z isomers.