Peptide synthesis. Part 7. Solid-phase synthesis of conotoxin G1

Abstract

The neurotoxin conotoxin G1 from Conus geographus has been synthesised by a solid-phase method using fluorenylmethoxycarbonylamino acids and a polar, poly(dimethylacrylamide)-based support. The two disulphide bridges were formed selectively by differential protection of cysteine residues using S-acetamidomethyl and S-t-butylsulphenyl groups.