Concepedia

Cysteine Conjugation

Cysteine Conjugation is a site-specific antibody conjugation method that involves the covalent attachment of payloads to cysteine residues generated by partial reduction of interchain disulfide bonds in antibodies, distinguishing it from other conjugation strategies by its controlled targeting of thiol groups for improved homogeneity and stability.

709

Publications

40.2K

Citations

3.8K

Authors

840

Institutions

Publications per year

2017–2026

196

Parents

Publications

709

Effects of Drug Loading on the Antitumor Activity of a Monoclonal Antibody Drug Conjugate

Kevin J. Hamblett, Peter D. Senter, Dana F. Chace et al. · Clinical Cancer Research · 2004 · 1.2K citations

, , +17

The Reversible Modification Regulates the Membrane-Binding State of Apg8/Aut7 Essential for Autophagy and the Cytoplasm to Vacuole Targeting Pathway

Takayoshi Kirisako, Yoshinobu Ichimura, Hisashi Okada et al. · The Journal of Cell Biology · 2000 · 970 citations · Full text

, , +13

Redox-based reagents for chemoselective methionine bioconjugation

Shixian Lin, Xiaoyu Yang, Shang Jia et al. · Science · 2017 · 523 citations · Full text

, , +16

Organometallic palladium reagents for cysteine bioconjugation

Ekaterina V. Vinogradova, Chi Zhang, Alexander M. Spokoyny et al. · Nature · 2015 · 514 citations

, , +10

A Chemist's View of Melanogenesis

Shosuke Ito · Pigment Cell Research · 2003 · 505 citations

, , +13

1–5 of 709

Authors

3.8K

  1. GJ
    Gonçalo J. L. Bernardes

    University of Cambridge, United Kingdom

    15 publications · 1.4K citations

    14

    h-index

  2. JS
    James Stevens

    Centers for Disease Control and Prevention, United States

    14 publications · 679 citations

    12

    h-index

  3. VC
    Vijay Chudasama

    University College London, United Kingdom

    8 publications · 363 citations

    8

    h-index

  4. KR
    Katherine R. Kozak

    WuXi AppTec (China), China

    8 publications · 582 citations

    8

    h-index

  5. PD
    Peter D. Senter

    Seagen (United States), United States

    7 publications · 2.3K citations

    7

    h-index

1–5 of 3.8K

Institutions

840

  1. University of Lisbon

    Lisbon, Portugal

    17 h-index

    48 publications

    2.3K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    16 h-index

    80 publications

    4.3K citations

  3. Seagen (United States)

    Bothell, United States

    16 h-index

    129 publications

    32K citations

  4. University of Cambridge

    Cambridge, United Kingdom

    14 h-index

    69 publications

    3.8K citations

  5. Scripps Research Institute

    San Diego, United States

    14 h-index

    66 publications

    4.9K citations

  6. University of California, Los Angeles

    Los Angeles, United States

    10 h-index

    39 publications

    6.1K citations

  7. Massachusetts Institute of Technology

    Cambridge, United States

    10 h-index

    42 publications

    5.1K citations

  8. University College London

    London, United Kingdom

    10 h-index

    60 publications

    2.9K citations

1–8 of 840

Venues

  1. Bioconjugate Chemistry

    77 publications · 5.1K citations

    39

    h-index

  2. Journal of Biological Chemistry

    JBC · 45 publications · 2.5K citations

    30

    h-index

  3. Journal of the American Chemical Society

    JACS · 33 publications · 3.4K citations

    28

    h-index

  4. Biochemistry

    26 publications · 1.3K citations

    21

    h-index

  5. Angewandte Chemie International Edition

    16 publications · 1.4K citations

    16

    h-index

1–5