Publication | Closed Access
Synthesis and biochemical evaluation of O-acetyl-ADP-ribose and N-acetyl analogs
22
Citations
34
References
2007
Year
Medicinal ChemistryBiochemistryNatural SciencesBioconjugationMolecular BiologyBiochemical EvaluationPeptide SynthesisProtein EngineeringStereoselective SynthesisHistone Protein H2a1.1Chemical BiologyNatural Product SynthesisEnzymatic ModificationSynthetic ChemistryMacro DomainBio-orthogonal ChemistryNovel Non-hydrolyzable Analogs
Synthetic routes for the preparation of O-acetyl-ADP-ribose and two novel non-hydrolyzable analogs containing an N-acetyl are described and shown to interact with the macro domain of histone protein H2A1.1.
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