Effect of serotonergic, corticostriatal and kainic acid lesions on the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6- tetrahydropyridine (MPTP) in mice

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

Kan Chiba, Anthony J. Trevor, Neal Castagnoli · Biochemical and Biophysical Research Communications · 1984 · 1.1K citations

Life Sciences, Neuroscience, Pharmacology +14

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

Richard E. Heikkila, Lawrence Manzino, Felicitas S. Cabbat et al. · Nature · 1984 · 1K citations

Medicine, Neuroscience, Pharmacology +14

Dopaminergic Neurotoxicity of 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine in Mice

Richard E. Heikkila, Arthur Hess, Roger C. Duvoisin · Science · 1984 · 1K citations

Medicine, Neuroscience, Pharmacology +17

Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism

Sanford P. Markey, Jan N. Johannessen, Chuang C. Chiueh et al. · Nature · 1984 · 780 citations

Medicine, Neuroscience, Pharmacology +11

Pargyline Prevents MPTP-Induced Parkinsonism in Primates

J. William Langston, Ian Irwin, Elizabeth B. Langston et al. · Science · 1984 · 583 citations

Medicine, Neuroscience, Pharmacology +17