Concepedia

Prostaglandin E<sub>2</sub> exacerbates collagen‐induced arthritis in mice through the inflammatory interleukin‐23/interleukin‐17 axis

Amir F. Sheibanie, Tanzilya Khayrullina, Fayez Safadi, Doina Ganea

Arthritis & Rheumatism · 2007 · 146 citations · 42 references

DOI

Abstract

Our results indicate that PGE(2) enhances DC-derived IL-6 production and induces a shift in the IL-23/IL-12 balance in favor of IL-23, resulting in increased IL-17 production, presumably through the amplification of self-reactive Th17 cells.

References

42

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Estelle Bettelli, Yijun Carrier, Wenda Gao et al. · Nature · 2006 · 6.8K citations

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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

Heon Park, Zhaoxia Li, Xuexian O. Yang et al. · Nature Immunology · 2005 · 4.2K citations · Full text

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TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

Marc Veldhoen, Richard J. Hocking, Christopher J. Atkins et al. · Immunity · 2006 · 3.6K citations · Full text

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Paul R. Mangan, Laurie E. Harrington, Darrell B. O’Quinn et al. · Nature · 2006 · 3K citations

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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

J. Daniel, Jonathan Sherlock, Yi Chen et al. · Nature · 2003 · 2.9K citations

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