Journal of Clinical Psychopharmacology · 2012 · 36 citations · 18 references
Life SciencesGeneticsPsychiatryHuman GeneticsPharmacogeneticsPharmacogenomicsClinical Implementation Of PharmacogeneticsNeurodevelopmental GeneticsNeuropsychiatric GeneticsPharmacogenetic TestingPopulation PharmacogeneticsPsychiatric GeneticsAdhd GeneticsAttention-deficit/hyperactivity Disorder GeneticsGenetic Risk VariantsMethylphenidate TherapyPharmacogenetic StudiesPharmacogenetic SusceptibilityPharmacogenetics Of Stimulant ResponseSerotonin Receptor Polymorphisms
Results from pharmacogenetic investigations of methylphenidate (MPH) response in patients with ADHD are still inconsistent, especially among adults. This study investigates the role of genetic variants (SLC6A4, HTR1B, TPH2, DBH, DRD4, COMT, and SNAP25) in the response to MPH in a sample of 164 adults. Genes were chosen owing to previous evidence for an influence in ADHD susceptibility. No significant differences in allele or genotype frequencies between MPH responders and nonresponders were detected. In conclusion, our findings do not support an effect of these genes in the pharmacogenetics of MPH among adults with ADHD.
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Michael Rösler, Roland Fischer, Richard Ammer et al. · European Archives of Psychiatry and Clinical Neuroscience · 2009 · 156 citations