Experimental Aging Research · 1976 · 52 citations · 8 references
Survival data are reported for 572 male non-breeding Fischer rats, representing offspring from brother-sister matings, maintained at a constant temperature and humidity, exposed to twelve hours of artificial lighting and to twelve hours of darkness per day, and fed a standard laboratory diet ad libitum. The mean longevity for these male rats was 642 days and the median longevity was 659 days; the longest-lived individual survived to 1192 days. Animals surviving beyond the median life span for this colony were found to lose a greater percentage of body weight during the last few weeks before death than did shorter-lived animals. Offspring born of parents one year of age showed no significant difference in longevity from those of three-month old parents. Moreover, the longer any animal lived, the greater the maximan weight which he obtained.
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A Transmissible, Cumulative, and Reversible Factor in Aging
Albert I. Lansing · Journal of Gerontology · 1947 · 270 citations
Biology, Lifespan Extension, Aging +12
Growth, Disease, and Aging in the Rat
B. N. Berg, Charles R. Harmison · Journal of Gerontology · 1957 · 62 citations
THE INFLUENCE OF AGE ON LITTER-SIZE
D. L. Ingram, Anita M. Mandl, S. Zuckerman · Journal of Endocrinology · 1958 · 47 citations