ChemMedChem · 2011 · 18 citations · 31 references
Life SciencesImmunologyPharmacologyImmunopharmacologyInnate ImmunitySignal TransductionAdjuvant DesignInnate Immune ReceptorsInnate Immune ResponseInnate Immune Signaling PathwaysLipid SignalingToll-like ReceptorsAgonist ActivityInnate Immune Receptor AgonistsSynthetic AdjuvantsSynthetic Receptor EngineeringVaccine Adjuvant DevelopmentVaccine Adjuvant Therapy
The sincerest form of flattery! A novel, symmetric lipid A mimetic (D1) formed by two glucose units linked through a 6-6' succinic diamide linker is active in modulating the activity of human TLR4. D1 inhibits endotoxin-stimulated TLR4 activation by inhibiting interaction of endotoxin with both receptors CD14 and MD-2 (associated to TLR4). D1 also has weak TLR4 agonist activity that makes it a promising lead compound for development as a vaccine adjuvant.
31
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene
Alexander Poltorak, Xiaolong He, Irina Smirnova et al. · Science · 1998 · 7.6K citations
CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein
Samuel D. Wright, Robert Ramos, Peter S. Tobias et al. · Science · 1990 · 4K citations
The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex
Beom Seok Park, Dong Hyun Song, Ho Min Kim et al. · Nature · 2009 · 2.4K citations