Murine double-minute 2 homolog single nucleotide polymorphism 309 and the risk of gynecologic cancer

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

Marc S. Greenblatt, W P Bennett, Monica Hollstein et al. · PubMed · 1994 · 3.5K citations

Medicine, Genetics, Molecular Genetics +16

Regulation of p53 stability by Mdm2

Michael H.G. Kubbutat, Stephen N. Jones, Karen H. Vousden · Nature · 1997 · 3.3K citations

Life Sciences, Cancer Biology, Molecular Biology +10

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

Vjekoslav Dulić, William K. Kaufmann, S J Wilson et al. · Cell · 1994 · 1.5K citations

Medicine, Cell Biology, Oncology +17

A Single Nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumor Suppressor Pathway and Accelerates Tumor Formation in Humans

Gareth L. Bond, Wenwei Hu, Elisabeth E. Bond et al. · Cell · 2004 · 1.3K citations · Full text

Medicine, Genetics, Molecular Genetics +15

mdm-2 Inhibits the G₁ Arrest and Apoptosis Functions of the p53 Tumor Suppressor Protein

Jiandong Chen, Xiangwei Wu, Jiayuh Lin et al. · Molecular and Cellular Biology · 1996 · 352 citations · Full text

Life Sciences, Molecular Biology, Oncology +17