Chloride intracellular channel 4 involves in the reduced invasiveness of cancer cells treated by photodynamic therapy

Abstract

Our results showed that the reduced expression of CLIC4 could further down-regulate MMP9 and result in the suppression of invasion in cancer cells treated with PDT. These results provide an insight into a new mechanism by which PDT affects the metastatic potential of cancer cells through down-regulation of MMP9 by CLIC4.