Autoradiographic discrimination of melanocortin receptors indicates that the MC3 subtype dominates in the medial rat brain

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

Dennis Huszar, Catherine Lynch, Victoria Fairchild-Huntress et al. · Cell · 1997 · 3K citations · Full text

Medicine, Endocrinology, Neuroscience +11

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

Wei Fan, Bruce A. Boston, Robert A. Kesterson et al. · Nature · 1997 · 1.9K citations

Life Sciences, Neurobiology, Neuroscience +14

The Cloning of a Family of Genes That Encode the Melanocortin Receptors

Kathleen G. Mountjoy, Linda S. Robbins, Marty Mortrud et al. · Science · 1992 · 1.6K citations

Life Sciences, Endocrinology, Molecular Biology +14

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.

Kathleen G. Mountjoy, Marty Mortrud, Malcolm J. Low et al. · Molecular Endocrinology · 1994 · 1.1K citations · Full text

Life Sciences, Neurobiology, Neuroscience +17