Early and exclusive use of norepinephrine in septic shock

The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure

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Veterinary Medicine, Internal Medicine, Critical Care Medicine +12

A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study

J. R. Le Gall · JAMA · 1993 · 6.4K citations

Medicine, Internal Medicine, Acute Care Medicine +9

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

Gordon R. Bernard, Jean‐Louis Vincent, Pierre‐François Laterre et al. · New England Journal of Medicine · 2001 · 6.1K citations · Full text

Medicine, Pharmacology, Pharmacotherapy +13

Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial

Rinaldo Bellomo, Marianne J. Chapman, Simon Finfer et al. · The Lancet · 2000 · 994 citations

Medicine, Pharmacology, Pharmacotherapy +13

Efficacy and Safety of Tifacogin (Recombinant Tissue Factor Pathway Inhibitor) in Severe Sepsis

Edward Abraham, Konrad Reinhart, Steven M. Opal et al. · JAMA · 2003 · 957 citations

Medicine, Pharmacology, Pharmacotherapy +15