3,4-Disubstituted oxazolidin-2-ones as constrained ceramide analogs with anticancer activities

The sphingomyelin cycle and the second messenger function of ceramide.

Yusuf A. Hannun · Journal of Biological Chemistry · 1994 · 1.3K citations · Full text

Life Sciences, Biochemistry, Cell Biology +14

Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB

Cun-Yu Wang, James C. Cusack, Rong Liu et al. · Nature Medicine · 1999 · 994 citations

Medicine, Cancer Biology, Oncology +14

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.

Adriana Haimovitz‐Friedman, C. Kan, Desiree Ehleiter et al. · The Journal of Experimental Medicine · 1994 · 902 citations · Full text

Life Sciences, Cell Biology, Oncology +17

A tetrazolium-based colorimetric MTT assay to quantitate human monocyte mediated cytotoxicity against leukemic cells from cell lines and patients with acute myeloid leukemia

Arjan A. van de Loosdrecht, R.H.J. Beelen, GJ Ossenkoppele et al. · Journal of Immunological Methods · 1994 · 802 citations · Full text

Medicine, Hematology, Oncology +7

Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.

M Y Kim, C.M. Linardic, Lina M. Obeid et al. · Journal of Biological Chemistry · 1991 · 631 citations · Full text

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