Extent and Patterns of <i>MGMT</i> Promoter Methylation in Glioblastoma- and Respective Glioblastoma-Derived Spheres

Abstract

In MGMT-methylated glioblastoma, MGMT promoter methylation is highly enriched in GS that supposedly comprise glioma-initiating cells. Thus, even a low percentage of MGMT methylation measured in a glioblastoma sample may be relevant and predict benefit from an alkylating agent therapy.