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N. Kudo, Barbara Wolff, Toshihiro Sekimoto et al. · Experimental Cell Research · 1998 · 824 citations

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Stereoselective Glycosylations of a Family of 6-Deoxy-1,2-glycals Generated by Catalytic Alkynol Cycloisomerization

Frank E. McDonald, K. Subba Reddy · Journal of the American Chemical Society · 2000 · 216 citations

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