Mu receptor binding of some commonly used opioids and their metabolites

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Pharmacological characterization of morphine-6 beta-glucuronide, a very potent morphine metabolite.

Dennis Paúl, Kelly M. Standifer, Charles E. Inturrisi et al. · Journal of Pharmacology and Experimental Therapeutics · 1989 · 395 citations

Medicine, Medicinal Chemistry, Pharmacology +15

Morphine-6-glucuronide, a potent mu agonist

Gavril W. Pasternak, Richard J. Bodnar, Janet A. Clark et al. · Life Sciences · 1987 · 364 citations

Medicine, Medicinal Chemistry, Pharmacology +10

Evidence from opiate binding studies that heroin acts through its metabolites

Charles E. Inturrisi, Michael Schultz, Sang J. Shin et al. · Life Sciences · 1983 · 213 citations

Medicine, Medicinal Chemistry, Pharmacology +11

Morphine-6-glucuronide: Analgesic effects and receptor binding profile in rats

Frances V. Abbott, Roberta M. Palmour · Life Sciences · 1988 · 192 citations

Medicine, Medicinal Chemistry, Pharmacology +11