Antimutagenic Activity of Sakuranetin from <i>Prunus Jamasakura</i>

Abstract

ABSTRACT: Sakuranetin (compound 1) from bark of Prunus jamasakura showed a suppressive effect on umu gene expression of SOS response in Salmonella typhimurium TA1535/pSK1002 against the mutagen furylfuramide. Gene expression was suppressed 83% at a concentration of 0.70 μmol/mL. The ID50 value of compound 1 was 0.30 μmol/mL. This compound showed the suppression of 4NQO, MNNG, Trp‐P‐1, AfB1, activated Trp‐P‐1, and UV irradiation‐induced SOS response. The methylated derivative (compound 2) of compound 1 showed less suppressive effect against all mutagens than compound 1. The antimutagenic activities of compounds 1 and 2 against furylfuramide, Trp‐P‐1, and activated Trp‐P‐1 were assayed by the Ames test using the S. typhimurium TA100 strain.