A novel series of IKKβ inhibitors part I: Initial SAR studies of a HTS hit

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

John Woronicz, Xiong Gao, Zhaodan Cao et al. · Science · 1997 · 1.2K citations

Life Sciences, Cell Biology, Molecular Biology +16

Identification and Characterization of an IκB Kinase

Catherine H. Régnier, Ho Yeong Song, Xiong Gao et al. · Cell · 1997 · 1.2K citations · Full text

Life Sciences, Immunology, Molecular Biology +10

Abnormal Morphogenesis But Intact IKK Activation in Mice Lacking the IKKα Subunit of IκB Kinase

Yinling Hu, Véronique Baud, Mireille Delhase et al. · Science · 1999 · 826 citations

Life Sciences, Cell Biology, Molecular Biology +14

IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation

Toby Lawrence, Magali Bébien, George Y. Liu et al. · Nature · 2005 · 623 citations

Life Sciences, Cell Biology, Immunology +14

Novel IKK inhibitors: β-carbolines

Alfredo Castro, François Soucy, Louis Grenier et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 241 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +7