In vivo evidence that the rise in plasma IL 6 following injection of a fever-inducing dose of LPS is mediated by IL 1β

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

C A Dinarello, Joseph G. Cannon, S. M. Wolff et al. · The Journal of Experimental Medicine · 1986 · 1.5K citations · Full text

Life Sciences, Immunology, Pharmacology +12

Production of hybridoma growth factor by human monocytes

Lucien A. Aarden, Els R. de Groot, Otto L. Schaap et al. · European Journal of Immunology · 1987 · 1.1K citations

Life Sciences, Cell Biology, Immunology +9

Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits.

John C. Mathison, Eliza B. Wolfson, Richard J. Ulevitch · Journal of Clinical Investigation · 1988 · 595 citations · Full text

Veterinary Medicine, Immunology, Pathobiology +17

Interleukin 6 is involved in interleukin 1‐induced activities

Maarten Helle, Just P. J. Brakenhoff, Els R. de Groot et al. · European Journal of Immunology · 1988 · 412 citations

Life Sciences, Cell Biology, Immunology +14

Tumor necrosis factor and interleukin-1β: suppression of food intake by direct action in the central nervous system

Carlos R. Plata‐Saláman, Yutaka Oomura, Yukihiro Kai · Brain Research · 1988 · 412 citations

Life Sciences, Immunology, Neurobiology +11