Disposition of leucovorin and its metabolites in dietary folic acid-deplete mice - comparison between tumor, liver and plasma

Clinical pharmacokinetics; concepts and applications

General Pharmacology The Vascular System · 1989 · 2.2K citations

Pharmacy, Clinical Pharmacokinetics, Pharmacokinetics +12

Phase II study of fluorouracil and its modulation in advanced colorectal cancer: a Southwest Oncology Group study.

Cynthia G. Leichman, Thomas R. Fleming, Franco M. Muggia et al. · Journal of Clinical Oncology · 1995 · 361 citations

Medicine, Oncology, Pharmacology +17

Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer.

T Buroker, M J O'Connell, Harry S. Wieand et al. · Journal of Clinical Oncology · 1994 · 312 citations

Medicine, Oncology, Pharmacotherapy +13

Pharmacokinetics of the diastereoisomers of leucovorin after intravenous and oral administration to normal subjects.

James A. Straw, Daniele Szapary, William T. Wynn · PubMed · 1984 · 140 citations

Pharmacy, Pharmacokinetics, Pharmacology +12

Pharmacokinetics of Leucovorin Metabolites in Human Plasma as a Function of Dose Administrated Orally and Intravenously

David G. Priest, John C. Schmitz, Marlene A. Bunni et al. · JNCI Journal of the National Cancer Institute · 1991 · 88 citations

Medicine, Pharmacokinetics, Pharmacology +7