Organic Letters · 2010 · 72 citations · 8 references
Life SciencesBiochemistryMicrobiologyAntimicrobial PharmacologyDrug DiscoveryMycologyAntifungal AgentsAntifungal PharmacologyAntimicrobial PeptidesFungal BiochemistryFungal BiotechnologyFungal Secondary MetabolitesAmino AcidsAntifungal PeptidesBioactive Fungal MetabolitesFungal Bioactive CompoundsFungal Biocontrol AgentsFungal Drug DiscoveryNatural Antifungal CompoundsNew Antifungal Agents
Potent antifungal cyclic lipopeptides, burkholdines (Bk), were isolated from a culture of Burkholderia ambifaria 2.2N. Bk-1229 (1) and Bk-1097 (2) are octapeptides comprised of nonproteinogenic amino acids, including beta-hydroxytyrosine, beta-hydroxyasparagine, and a new fatty acyl amino acid. 1 and 2 are fungicidal against a panel of fungi with potencies 2-60-fold better than amphotericin B control.
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Tom Coenye, Eshwar Mahenthiralingam, Deborah A. Henry et al. · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · 2001 · 260 citations
Chemical Cleavage at Aspartyl Residues for Protein Identification
Aiqun Li, Raymond C. Sowder, Louis E. Henderson et al. · Analytical Chemistry · 2001 · 144 citations