Nuclear Lamin A/C Deficiency Induces Defects in Cell Mechanics, Polarization, and Migration

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Sayda M. Elbashir, Jens Harborth, Winfried Lendeckel et al. · Nature · 2001 · 9.4K citations

Life Sciences, Molecular Biology, Molecular Genetics +7

Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

Maria Eriksson, W. Ted Brown, Leslie B. Gordon et al. · Nature · 2003 · 2.2K citations · Full text

Medicine, Genetics, Molecular Genetics +5

Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure

Andrew J. Maniotis, Christopher S. Chen, Donald E. Ingber · Proceedings of the National Academy of Sciences · 1997 · 1.6K citations

Life Sciences, Biophysics, Cell Biology +17

Coupling of the nucleus and cytoplasm: Role of the LINC complex

Melissa Crisp, Qian Liu, Kyle J. Roux et al. · The Journal of Cell Biology · 2005 · 1.4K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

Missense Mutations in the Rod Domain of the Lamin A/C Gene as Causes of Dilated Cardiomyopathy and Conduction-System Disease

Diane Fatkin, Calum A. MacRae, Takeshi Sasaki et al. · New England Journal of Medicine · 1999 · 1.4K citations · Full text

Medicine, Genetics, Molecular Genetics +17