Concepedia

Synthesis of the mannosidase inhibitors swainsonine and 1,4-dideoxy-1,4-imino-D-mannitol and of the ring contracted swainsonines, (1S, 2R, 7R, 7aR)-1,2,7-trihydroxypyrrolizidine and (1S, 2R, 7S, 7aR)-1,2,7-trihydroxypyrrolizidine

Neil M. Carpenter, George W. J. Fleet, Isabelle Cenci di Bello, Bryan Winchester, Linda E. Fellows, Robert J. Nash

Tetrahedron Letters · 1989 · 58 citations · 17 references

DOI

Concepts

References

17

Swainsonine inhibits the biosynthesis of complex glycoproteins by inhibition of Golgi mannosidase II.

Daulat R.P. Tulsiani, Thomas M. Harris, Oscar Touster · Journal of Biological Chemistry · 1982 · 464 citations · Full text

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Effects of swainsonine and polyinosinic:polycytidylic acid on murine tumor cell growth and metastasis.

James W. Dennis · PubMed · 1986 · 204 citations

, , +15

Glycosidase inhibition by plant alkaloids which are structural analogues of monosaccharides

Stephen V. Evans, Linda E. Fellows, Tony K. M. Shing et al. · Phytochemistry · 1985 · 182 citations

, , +16

Augmentation of murine natural killer cell activity by swainsonine, a new antimetastatic immunomodulator.

Martin J. Humphries, Kazue Matsumoto, Sandra L. White et al. · PubMed · 1988 · 106 citations

, , +16

Studies of an immunomodulator, swainsonine. II. Effect of swainsonine on mouse immunodeficient system and experimental murine tumor.

TOHRU KINO, Noriaki Inamura, Kunio Nakahara et al. · The Journal of Antibiotics · 1985 · 103 citations · Full text

, , +10