George W. J. Fleet

Glucose analog inhibitors of glycogen phosphorylase: the design of potential drugs for diabetes

Jennifer L. Martin, K. Veluraja, K. Ross et al. · Biochemistry · 1991 · 109 citations

Life Sciences, Biochemistry, Pharmacology +10

Glucose analogue inhibitors of glycogen phosphorylase: from crystallographic analysis to drug prediction using GRID force-field and GOLPE variable selection

Kimberly A. Watson, Edward P. Mitchell, L.N. Johnson et al. · Acta Crystallographica Section D Biological Crystallography · 1995 · 70 citations

Life Sciences, Biochemistry, Pharmacology +17

Synthesis of 2-Acetamido-1,5-imino-1,2,5-trideoxy-<scp>d</scp>-mannitol and of 2-Acetamido-1,5-imino-1,2,5-trideoxy-<scp>d</scp>-glucitol, a Potent and Specific Inhibitor of a Number of β-<i>N</i>-Acetylglucosaminidases

George W. J. Fleet, Paul W. Smith, Robert J. Nash et al. · Chemistry Letters · 1986 · 67 citations

Pharmacy, Medicinal Chemistry, Carbohydrate Chemistry +10

N‐acetyl‐<i>β</i>‐D‐glucopyranosylamine: A potent T‐state inhibitor of glycogen phosphorylase. A comparison with <i>α</i>‐D‐glucose

Nikos G. Oikonomakos, Maria Kontou, S.E. Zographos et al. · Protein Science · 1995 · 60 citations · Full text

Life Sciences, Biochemistry, Pharmacology +14

Synthesis of the mannosidase inhibitors swainsonine and 1,4-dideoxy-1,4-imino-D-mannitol and of the ring contracted swainsonines, (1S, 2R, 7R, 7aR)-1,2,7-trihydroxypyrrolizidine and (1S, 2R, 7S, 7aR)-1,2,7-trihydroxypyrrolizidine

Neil M. Carpenter, George W. J. Fleet, Isabelle Cenci di Bello et al. · Tetrahedron Letters · 1989 · 58 citations

Pharmacy, Medicinal Chemistry, Pharmacology +5