Swainsonine inhibits the biosynthesis of complex glycoproteins by inhibition of Golgi mannosidase II.

Abstract

In glycoprotein biosynthesis, rat liver Golgi mannosidases IA and IB are a-1,2-specific and convert Mans oligosaccharides to the corresponding Mans species, whereas mannosidase I1 cleaves a-1,3-and a-1,g-man-nosy1 residues from GlcNAcMan5 in completing the mannosyl trimming process (Tulsiani, D.