Publication | Open Access

Lead optimization of 5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxyhexanamides to reduce a cardiac safety issue: Discovery of DS-8108b, an orally active renin inhibitor

Medicinal ChemistryCardiac Safety IssueBiochemistryMedicineNatural SciencesRational Drug DesignLead IdentificationPharmacotherapyActive Renin InhibitorDrug DevelopmentChemical BiologyPharmacologyPharmaceutical ChemistryDrug DiscoveryLead Optimization