Pregnane X receptor suppresses proliferation and tumourigenicity of colon cancer cells

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

J�rgen Lehmann, David D. McKee, M. A. Watson et al. · Journal of Clinical Investigation · 1998 · 1.6K citations · Full text

Genetics, Cyp3a4 Gene, Mouse Pxr Reveals +18

SXR, a novel steroid and xenobioticsensing nuclear receptor

Bruce Blumberg, Walid Sabbagh, Henry Juguilon et al. · Genes & Development · 1998 · 917 citations · Full text

Metabolomic Profiling, Novel Steroid, Metabolic Signaling +18

Identification of a human nuclear receptor defines a new signaling pathway for <i>CYP</i> <i>3</i> A induction

Göran Bertilsson, Jessica Heidrich, Kristian Svensson et al. · Proceedings of the National Academy of Sciences · 1998 · 868 citations · Full text

United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition)

British Journal of Cancer · 1998 · 654 citations · Full text

Experimental Neoplasia, Animal Testing, Second Edition +10

Trends in cancer incidence and mortality in Scotland: description and possible explanations

I dos Santos Silva, Andrew Reid, Zhijiao Qiao et al. · British Journal of Cancer · 1998 · 533 citations · Full text

Epidemiology, Preventive Medicine, Cancer Epidemiology +9