Radioligand—receptor binding studies: what's wrong with the scatchard analysis?

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

George Scatchard · Annals of the New York Academy of Sciences · 1949 · 19.9K citations

Natural Sciences, Biophysics, Chemistry +9

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

Peter J. Munson, David Rodbard · Analytical Biochemistry · 1980 · 8.5K citations

Life Sciences, Chemistry, Biomolecular Modeling +11

Numbers of Receptor Sites from Scatchard Graphs: Facts and Fantasies

Irving M. Klotz · Science · 1982 · 678 citations

Medicine, Pharmacology, Cell Signaling +12

Mathematical theory of complex ligand-binding systems at equilibrium: Some methods for parameter fitting

Henry A. Feldman · Analytical Biochemistry · 1972 · 618 citations

Natural Sciences, Chemistry, Complex Systems +15

Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes.

A. De Léan, Arthur A. Hancock, Robert J. Lefkowitz · Molecular Pharmacology · 1982 · 594 citations

Medicine, Pharmacology, Molecular Pharmacology +14